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Phentermine is a prescription medication approved by the FDA for short-term weight management in adults with obesity or weight-related conditions. It functions as an appetite suppressant by stimulating the central nervous system, leading to reduced hunger and increased energy expenditure. Typically prescribed for a duration of 3 to 12 weeks, phentermine is intended to be used in conjunction with a reduced-calorie diet and increased physical activity.

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Clinical Overview:

• FDA Approval: Phentermine has been FDA-approved since 1959 for short-term weight management. 
• Mechanism of Action: Phentermine stimulates the release of norepinephrine in the brain, leading to appetite suppression. 
• Dosage: The recommended dosage is 15 to 37.5 mg once daily, taken before breakfast or 1 to 2 hours after breakfast. 
• Side Effects: Common side effects include dry mouth, insomnia, dizziness, and increased heart rate. Serious side effects may involve chest pain, shortness of breath, or swelling. 
• Contraindications: Phentermine should not be used by individuals with a history of cardiovascular disease, uncontrolled high blood pressure, glaucoma, hyperthyroidism, or a history of drug abuse.